翻訳と辞書 Words near each other ・ Methyl group ・ Methyl halide transferase ・ Methyl hydroxychalcone ・ Methyl hypochlorite ・ Methyl iodide ・ Methyl isobutyl ketone ・ Methyl isocyanate ・ Methyl isocyanide ・ Methyl isoeugenol ・ Methyl isopropyl ketone ・ Methyl isothiocyanate ・ Methyl jasmonate ・ Methyl lactate ・ Methyl methacrylate ・ Methyl methacrylate (data page) ・ Methyl methanesulfonate ・ Methyl nitrate ・ Methyl nitrite ・ Methyl orange ・ Methyl pentanoate ・ Methyl phenkapton ・ Methyl phenylacetate ・ Methyl propionate ・ Methyl radical ・ Methyl red ・ Methyl salicylate ・ Methyl tert-butyl ether ・ Methyl thiocyanate ・ Methyl trifluoromethansulfonate ・ Methyl vinyl ether Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Methyl methanesulfonate ： ウィキペディア英語版 Methyl methanesulfonate |Section2= |Section3= |Section4= }} Methyl methanesulfonate (MMS) is an alkylating agent and a carcinogen. It is also a suspected reproductive toxicant, and may also be a skin/sense organ toxicant.〔(Scorecard Pollution Information Site: Methyl Methanesulfonate ) Scorecard.org Accessed 14 Feb 08〕 It is used in cancer treatment.〔(Medical.Webends.com: Methyl Methanesulfonate ) Medical.webends.com Accessed 14 Feb 08〕 ==Chemical reactions with DNA== MMS methylates DNA predominantly on N7-deoxyguanosine and N3-deoxyadenosine, and to a much lesser extent also methylates at other oxygen and nitrogen atoms in DNA bases, and also methylates the phosphodiester linkage. Originally, this action was believed to directly cause double-stranded DNA breaks, because homologous recombination-deficient cells are particularly vulnerable to the effects of MMS. However, it is now believed that MMS stalls replication forks, and cells that are homologous recombination-deficient have difficulty repairing the damaged replication forks.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Methyl methanesulfonate」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.